Humanin

Humanin is a fascinating mitochondria-derived peptide (MDP) discovered in the early 2000s. It’s a small protein encoded by mitochondrial DNA, known for its cytoprotective, anti-aging, and neuroprotective properties. Research on Humanin is still emerging, but it’s considered a key player in cell survival and longevity pathways.

Key Benefits of Humanin

1. Anti-Aging & Longevity

• Activates cell survival pathways and reduces age-related cellular damage.
• Works via IGF-1 and STAT3 signaling pathways to protect mitochondria and prevent apoptosis (cell death).
• Higher levels of Humanin have been linked to longer lifespan in animal studies.

2. Neuroprotection

• Protects neurons from oxidative stress, amyloid-beta toxicity (linked to Alzheimer’s), and apoptosis.
• May reduce the risk or progression of neurodegenerative diseases like Alzheimer’s and Parkinson’s.

3. Insulin Sensitivity & Metabolic Health

• Improves glucose uptake and insulin sensitivity.
• May help reduce the risk of type 2 diabetes, obesity, and metabolic syndrome.

4. Cardioprotection

• Shields heart cells from ischemia-reperfusion injury and oxidative damage.
• Helps maintain cardiovascular health, especially under stress or aging conditions.

5. Anti-Inflammatory Effects

• Suppresses inflammatory cytokines like TNF-α and IL-6.
• Supports systemic balance in inflammatory and autoimmune conditions.

6. Mitochondrial Health

• Helps maintain mitochondrial function and biogenesis.
• Critical for energy metabolism, cellular repair, and protection against age-related decline.