PE-22-88 10MG

PE-22-28 is a synthetic peptide derivative of Spadin, which itself is derived from the neurotensin receptor ligand sortilin. It’s a novel antidepressant candidate with fast-acting effects.

Key Benefits of PE-22-28:

1. Rapid Antidepressant Effects

• Works very quickly in terms of speed, but without dissociative or addictive side effects.
• Onset is within hours, compared to weeks for traditional antidepressants.

2. TREK-1 Channel Inhibition

• PE-22-28 inhibits TREK-1 (TWIK-related K+ channel), which is linked to mood regulation, neuronal excitability, and neuroplasticity.
• TREK-1 is often overactive in depression, and blocking it can help rebalance mood and emotional processing.

3. Neuroprotective Properties

• Enhances BDNF (Brain-Derived Neurotrophic Factor) signaling, which supports neuron health and connectivity.
• May promote neurogenesis (formation of new brain cells), especially in the hippocampus.